Product Overview
Ethacrynic acid | T4564 | TargetMol Chemicals
CAS: 58-54-8
Smiles: CCC(=C)C(=O)c1ccc(OCC(O)=O)c(Cl)c1Cl
Formula: C13H12Cl2O4
Pathway: Membrane transporter/Ion channel|||Metabolism|||NF-Κb|||Others|||oxidation-reduction
Target: Others|||Calcium Channel|||NF-κB|||GST
Receptor: N/A
Bioactivity: Ethacrynic acid is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase and Wnt signalling, producing cytotoxicity in chronic lymphocytic leukaemia cells and other tumour cells.
Molecular Weight: 303, 14
