Product Overview
Excisanin A | TN4046 | TargetMol Chemicals
CAS: 78536-37-5
Smiles: CC1(C)CC[C@H](O)[C@@]2(C)[C@@H]3C[C@H](O)[C@@H]4[C@@H](O)[C@@]3([C@H](O)C[C@H]12)C(=O)C4=C
Formula: C20H30O5
Pathway: Angiogenesis|||Apoptosis|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||DNA Damage/DNA Repair|||GPCR/G Protein|||Immunology/Inflammation|||MAPK|||NF-Κb|||PI3K/Akt/mTOR signaling|||Proteases/Proteasome|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: MMP|||FAK|||PARP|||GSK-3|||NF-κB|||Wnt/beta-catenin|||Akt|||Caspase|||PI3K|||Prostaglandin Receptor|||JNK
Receptor: N/A
Bioactivity: ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP).
Molecular Weight: 350, 44
