Product Overview
Flavopiridol | T6837 | TargetMol Chemicals
CAS: 146426-40-6
Smiles: CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl
Formula: C21H20ClNO5
Pathway: Apoptosis|||Autophagy|||Cell Cycle/Checkpoint|||Microbiology/Virology|||Proteases/Proteasome
Target: Apoptosis|||HIV Protease|||CDK|||Autophagy
Receptor: N/A
Bioactivity: Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2.
Molecular Weight: 401, 84
