Fosbretabulin Disodium | T6272

Fosbretabulin Disodium | T6272 | TargetMol Chemicals

CAS: 168555-66-6

Smiles: [Na+].[Na+].COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1OP([O-])([O-])=O

Formula: C18H19Na2O8P

Pathway: Apoptosis|||Cytoskeletal Signaling

Target: Apoptosis|||Microtubule Associated

Receptor: N/A

Bioactivity: Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium inhibits the polymerization of tubulin (IC50: 2.4 μM), and also disrupts tumor vasculature.

Molecular Weight: 440, 295