Product Overview
GDC0575 monohydrochloride | T27407 | TargetMol Chemicals
CAS: 1196504-54-7
Smiles: Cl.N[C@@H]1CCCN(C1)c1c(Br)cnc2[nH]cc(NC(=O)C3CC3)c12
Formula: C16H21BrClN5O
Pathway: Cell Cycle/Checkpoint
Target: Chk
Receptor: N/A
Bioactivity: GDC-0575 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
Molecular Weight: 414, 73
