Product Overview
Griffipavixanthone | TN4166 | TargetMol Chemicals
CAS: 219649-95-3
Smiles: CC1=C[C@H]2[C@H]([C@@H](c3c2c2c(oc4cc(O)cc(O)c4c2=O)c(O)c3O)c2cc(O)c(O)c3oc4cc(O)cc(O)c4c(=O)c23)C(C)(C)C1
Formula: C36H28O12
Pathway: Apoptosis|||Immunology/Inflammation|||MAPK|||Proteases/Proteasome
Target: ERK|||Raf|||ROS|||MEK|||Caspase
Receptor: N/A
Bioactivity: Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. It can inhibit tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer.
Molecular Weight: 652, 6