Product Overview
Groenlandicine | TN1037 | TargetMol Chemicals
CAS: 38691-95-1
Smiles: COc1cc-2c(CC[n+]3cc4c5OCOc5ccc4cc-23)cc1O
Formula: C19H16NO4
Pathway: DNA Damage/DNA Repair
Target: Topoisomerase
Receptor: N/A
Bioactivity: Groenlandicine is a protoberberine alkaloid from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR). Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage;Groenlandicine may be a promising anti-Alzheimer's disease agent due to its potent inhibitory activity of both ChEs and beta-amyloids formation, as well as marked ONOO(-) scavenging and good ROS inhibitory capacities.
Molecular Weight: 322, 339