Product Overview
GSK-J1 | T6847 | TargetMol Chemicals
CAS: 1373422-53-7
Smiles: OC(=O)CCNc1cc(nc(n1)-c1ccccn1)N1CCc2ccccc2CC1
Formula: C22H23N5O2
Pathway: Chromatin/Epigenetic
Target: Histone Demethylase
Receptor: N/A
Bioactivity: GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, >10-fold selectivity over other tested demethylases.
Molecular Weight: 389, 459
