Product Overview
Halofuginone hydrobromide | T3524 | TargetMol Chemicals
CAS: 64924-67-0
Smiles: Br.O[C@@H]1CCCN[C@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
Formula: C16H18Br2ClN3O3
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Membrane transporter/Ion channel|||Metabolism|||Microbiology/Virology|||Others|||Stem Cells
Target: Others|||Calcium Channel|||DNA/RNA Synthesis|||Sodium Channel|||Parasite|||TGF-beta/Smad
Receptor: N/A
Bioactivity: Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
Molecular Weight: 495, 6
