Product Overview
HALOFUGINONE LACTATE | T8785 | TargetMol Chemicals
CAS: 82186-71-8
Smiles: CC(O)C(O)=O.O[C@@H]1CCCN[C@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
Formula: C19H23BrClN3O6
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Stem Cells
Target: DNA/RNA Synthesis|||TGF-beta/Smad
Receptor: N/A
Bioactivity: HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity
Molecular Weight: 504, 76
