Product Overview
Halofuginone | T6856 | TargetMol Chemicals
CAS: 55837-20-2
Smiles: O[C@@H]1CCCN[C@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
Formula: C16H17BrClN3O3
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Membrane transporter/Ion channel|||Metabolism|||Microbiology/Virology|||Stem Cells
Target: Calcium Channel|||DNA/RNA Synthesis|||Sodium Channel|||Parasite|||TGF-beta/Smad
Receptor: N/A
Bioactivity: Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase（Ki=18.3 nM）, could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
Molecular Weight: 414, 68
