Product Overview
HQ461 | T9849 | TargetMol Chemicals
CAS: 1226443-41-9
Smiles: Cc1cnc(NC(=O)Cc2csc(Nc3cccc(C)n3)n2)s1
Formula: C15H15N5OS2
Pathway: Cell Cycle/Checkpoint
Target: CDK
Receptor: N/A
Bioactivity: HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
Molecular Weight: 345, 44