Product Overview
Ilorasertib | TQ0059 | TargetMol Chemicals
CAS: 1227939-82-3
Smiles: Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Formula: C25H21FN6O2S
Pathway: Angiogenesis|||Apoptosis|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors
Target: VEGFR|||FLT|||c-RET|||PDGFR|||Aurora Kinase
Receptor: N/A
Bioactivity: Ilorasertib (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).
Molecular Weight: 488, 54