Product Overview
IRE1α kinase-IN-1 | T9564 | TargetMol Chemicals
CAS: 2328097-41-0
Smiles: CN1CCC(CNc2cc(Cl)nn3c2ncc3-c(cc2nc(Nc3ccccc3)[nH]c2c2)c2F)CC1
Formula: C26H26ClFN8
Pathway: Cell Cycle/Checkpoint
Target: IRE1
Receptor: N/A
Bioactivity: IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC50=80 nM)
Molecular Weight: 504, 99
