Product Overview
Irinotecan Hydrochloride | T0486L | TargetMol Chemicals
CAS: 100286-90-6
Smiles: Cl.CCc1c2cc(OC(=O)N3CCC(CC3)N3CCCCC3)ccc2nc2c1Cn1c2cc2c(COC(=O)[C@]2(O)CC)c1=O
Formula: C33H39ClN4O6
Pathway: Autophagy|||DNA Damage/DNA Repair
Target: Topoisomerase|||Autophagy
Receptor: N/A
Bioactivity: Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.
Molecular Weight: 623, 14
