Product Overview
IWP-051 | T32242 | TargetMol Chemicals
CAS: 1354041-91-0
Smiles: Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncc(F)c(=O)[nH]1
Formula: C17H11F2N5O2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans.
Molecular Weight: 355, 305
