Product Overview
Ixazomib | T2122 | TargetMol Chemicals
CAS: 1072833-77-2
Smiles: CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O
Formula: C14H19BCl2N2O4
Pathway: Apoptosis|||Autophagy|||Proteases/Proteasome|||Ubiquitination
Target: Proteasome|||Caspase|||Autophagy
Receptor: N/A
Bioactivity: MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites (IC50: 31/3500 nM).
Molecular Weight: 361, 03
