Product Overview
JAK2-IN-7 | T35900 | TargetMol Chemicals
CAS: 2593402-36-7
Smiles: CC(C)n1ncc(-c2c(C)cnc(Nc3cc(CCN(C4)C(/C=C/CN(C)C)=O)c4cc3)n2)c1
Formula: C26H33N7O
Pathway: Angiogenesis|||Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells
Target: JAK
Receptor: N/A
Bioactivity: JAK2-IN-7 is a selective JAK2 inhibitor with IC50s of 3, 11.7, and 41 nM for JAK2, SET-2, and Ba/F3V617F cells, respectively. JAK2-IN-7 possesses >14-fold selectivity over JAK1, JAK3, FLT3. JAK2-IN-7 stimulates cell cycle arrest in the G0/G1 phase and induces tumor cellapoptosis. Antitumor activities[1].
Molecular Weight: 459, 59
