Product Overview
JH-IX-179 | T32288 | TargetMol Chemicals
CAS: T32288
Smiles: O=C1C2=C(NC3=C2C=CC(C4=CNN=C4)=C3)C5=C1C=CC(C6=CN(CCCN(C)C)N=C6)=C5
Formula: C26H24N6O
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: JH-IX-179 is a novel type I ATP competitive and highly selective FLT3 inhibitor. JH-IX-179 is much more selective for FLT3 and FLT3 mutants than for Kronani. In addition, JH-IX-179 showed little human serum protein binding and effectively inhibited autophosphorylation of FLT3 and activity of downstream signaling molecules of FLT3-D835Y and FLT3-ITD.
Molecular Weight: 436, 52
