Product Overview
JH-VIII-157-02 | T15612 | TargetMol Chemicals
CAS: 1639422-97-1
Smiles: CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(CC(=O)N(C)C)c1
Formula: C28H27N5O2
Pathway: Angiogenesis|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors
Target: Microtubule Associated|||ALK
Receptor: N/A
Bioactivity: JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L.
Molecular Weight: 465, 557
