Product Overview
JH-XI-10-02 | T13743 | TargetMol Chemicals
CAS: 2209085-22-1
Smiles: [H][C@@]12CC[C@H](c3ccc4ccncc4c3)[C@@]1(C)CCC1[C@@]2([H])CCC2C[C@H](CC[C@]12C)N(C)C(=O)CCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
Formula: C53H69N5O9
Pathway: Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors
Target: EGFR
Receptor: N/A
Bioactivity: JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.
Molecular Weight: 920, 161
