Product Overview
JNJ-63576253 free base | T8933 | TargetMol Chemicals
CAS: 2110426-27-0
Smiles: FC(F)(F)c1cc(cnc1C#N)N1C(=S)N(c2ccc(OC3CCNCC3)nc2)C2(CCC2)C1=O
Formula: C23H21F3N6O2S
Pathway: Endocrinology/Hormones
Target: Androgen Receptor
Receptor: N/A
Bioactivity: JNJ-63576253 is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC).
Molecular Weight: 502, 52
