Product Overview
K-14585 | T27708 | TargetMol Chemicals
CAS: 880546-17-8
Smiles: NCCCC[C@H](NC(=O)CNC(=O)Nc1ccc2n(Cc3c(Cl)cccc3Cl)cc(CN3CCCC3)c2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NC(c1ccccc1)c1ccccc1
Formula: C51H56Cl2N8O4
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: K-14585 is a proteinase-activated receptor 2 antagonist. K-14585 inhibited PAR(2)-mediated p65 NFkappaB phosphorylation and NFkappaB-DNA binding. K-14585 inhibited SLIGKV-stimulated IL-8 production, but given alone increased IL-8.
Molecular Weight: 915, 96
