Kamebakaurin | TWS1977

(No reviews yet) Write a Review
Adding to cart… The item has been added

Product Overview

Kamebakaurin | TWS1977 | TargetMol Chemicals

CAS: 73981-34-7

Smiles: CC1(C)CC[C@H](O)[C@@]2(CO)[C@@H]3CC[C@@H]4[C@H](O)[C@@]3([C@H](O)C[C@H]12)C(=O)C4=C

Formula: C20H30O5

Pathway: NF-Κb

Target: NF-κB

Receptor: N/A

Bioactivity: 1. Kamebakaurin has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity. 3. Kamebakaurin has anti-cancer and anti-inflammatory activities through direct inhibition of DNA-binding activity of nuclear factor-kappa B (NF-κB) p50.4. Kamebakaurin has anti-neuroinflammatory activity via inhibition of c-Jun NH -terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells.

Molecular Weight: 350, 455


(No reviews yet) Write a Review