Product Overview
KRAS inhibitor-9 | T8756 | TargetMol Chemicals
CAS: 300809-71-6
Smiles: Nc1ccc(Sc2nc3ccccc3s2)c(Cl)c1
Formula: C13H9ClN2S2
Pathway: Apoptosis|||GPCR/G Protein|||MAPK
Target: Apoptosis|||Ras
Receptor: N/A
Bioactivity: KRAS inhibitor-9 is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells
Molecular Weight: 292, 8
