Product Overview
KU-0060648 | T6557 | TargetMol Chemicals
CAS: 881375-00-4
Smiles: CCN1CCN(CC(=O)Nc2ccc(-c3cccc4c3oc(cc4=O)N3CCOCC3)c3sc4ccccc4c23)CC1
Formula: C33H34N4O4S
Pathway: DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling
Target: DNA-PK|||PI3K|||mTOR
Receptor: N/A
Bioactivity: KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.
Molecular Weight: 582, 72
