Product Overview
Lenalidomide-C4-NH2 hydrochloride | T17878 | TargetMol Chemicals
CAS: T17878
Smiles: O=C(C(N(CC1=C2C=CC=C1CCCCN)C2=O)CC3)NC3=O.Cl
Formula: C17H22ClN3O3
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].
Molecular Weight: 351, 83
