Product Overview
MAC glucuronide α-hydroxy lactone-linked SN-38 | T18722 | TargetMol Chemicals
CAS: 2246380-70-9
Smiles: CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OCN(CCS(C)(=O)=O)C(=O)OCc4ccc(O[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)C(O)=O)c(NC(=O)CN(C)C(=O)CCN5C(=O)C=CC5=O)c4)c3=O)-c2nc2ccc(O)cc12
Formula: C50H54N6O20S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively[1].
Molecular Weight: 1091, 06
