Product Overview
Manassantin A | TN4489 | TargetMol Chemicals
CAS: 88497-87-4
Smiles: COc1ccc(cc1OC)C(O)C(C)Oc1ccc(cc1OC)C1OC(C(C)C1C)c1ccc(OC(C)C(O)c2ccc(OC)c(OC)c2)c(OC)c1
Formula: C42H52O11
Pathway: Angiogenesis|||Apoptosis|||Chromatin/Epigenetic|||GPCR/G Protein|||Immunology/Inflammation|||JAK/STAT signaling|||MAPK|||Neuroscience|||NF-Κb|||Stem Cells
Target: ERK|||cAMP|||TNF|||NF-κB|||MAPK|||COX|||HIF|||Prostaglandin Receptor|||JNK|||STAT
Receptor: N/A
Bioactivity: Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB activation, and improvements in the antioxidant and anti-inflammatory status.Manassantin A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases. Manassantin A inhibits cAMP-induced melanin production by down-regulating the gene expressions of MITF and tyrosinase in melanocytes.
Molecular Weight: 732, 9
