Product Overview
Manassantin B | TN4490 | TargetMol Chemicals
CAS: 88497-88-5
Smiles: COc1ccc(cc1OC)[C@@H](O)[C@@H](C)Oc1ccc(cc1OC)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(O[C@H](C)[C@H](O)c2ccc3OCOc3c2)c(OC)c1
Formula: C41H48O11
Pathway: Apoptosis|||JAK/STAT signaling|||MAPK|||Microbiology/Virology|||NF-Κb|||Stem Cells
Target: ERK|||BCL|||p38 MAPK|||TNF|||NF-κB|||JNK|||STAT|||Antifection
Receptor: N/A
Bioactivity: Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in part, via inhibition of cell proliferation and decrease of collagen production.
Molecular Weight: 716, 8
