Product Overview
MGS-0039 | T28034 | TargetMol Chemicals
CAS: 569686-87-9
Smiles: [H][C@@]12C[C@@H](OCc3ccc(Cl)c(Cl)c3)[C@@](N)(C(O)=O)[C@]1([H])[C@@]2(F)C(O)=O
Formula: C15H14Cl2FNO5
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: MGS-0039 is a group II metabotropic glutamate receptor (mgluR2/3) antagonist. Antidepressant-like action of group II mGlu receptor antagonists does not depend on serotonergic system activation. However, the AMPA receptor seems to play a key role in the antidepressant-like action of these compounds. Dopamine release in the NAc shell is regulated by mGlu 2/3 receptors.
Molecular Weight: 378, 18
