Product Overview
Milciclib | T6081 | TargetMol Chemicals
CAS: 802539-81-7
Smiles: CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc-21
Formula: C25H32N8O
Pathway: Autophagy|||Cell Cycle/Checkpoint|||Tyrosine Kinase/Adaptors
Target: Trk receptor|||CDK|||Autophagy
Receptor: N/A
Bioactivity: Milciclib (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7. Phase 2.
Molecular Weight: 460, 586