Species Reactivity Human, Rat
Host/Isotype Rabbit / IgG
Immunoge Full-length peptide corresponding to amino acids 1-16 on MOTS-c.
Concentration 0.5-1.5 mg/mL
Purification Affinity chromatography
Storage buffer proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains 0.02% sodium azide
Storage conditions -20°C
Regulates insulin sensitivity and metabolic homeostasis. Inhibits the folate cycle, thereby reducing de novo purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4-carboxamide (AICAR) and the activation of the metabolic regulator 5'-AMP-activated protein kinase (AMPK). Protects against age-dependent and diet-induced insulin resistance as well as diet-induced obesity.