Product Overview
Neferine | T5S1097 | TargetMol Chemicals
CAS: 2292-16-2
Smiles: COc1ccc(C[C@H]2N(C)CCc3cc(OC)c(Oc4cc(C[C@H]5N(C)CCc6cc(OC)c(OC)cc56)ccc4O)cc23)cc1
Formula: C38H44N2O6
Pathway: Apoptosis|||Autophagy|||NF-Κb
Target: Apoptosis|||NF-κB|||Autophagy
Receptor: N/A
Bioactivity: 1. Neferine has anti-tumor activities, Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to achieve anticancer synergism by curbing the toxicity. 3. Neferine inhibited high glucose-induced endothelial apoptosis via blocking ROS/Akt/NF-κB pathway, which provides the evidence for using Neferine to treat diabetic vasculopathy. 4. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species, activation of MAPKs, lipid peroxidation, depletion of cellular antioxidant pool, loss of mitochondrial membrane potential, and intracellular calcium accumulation.
Molecular Weight: 624, 778