Product Overview
Neoechinulin A | TN4635 | TargetMol Chemicals
CAS: 51551-29-2
Smiles: C[C@@H]1NC(=O)\C(NC1=O)=C\c1c([nH]c2ccccc12)C(C)(C)C=C
Formula: C19H21N3O2
Pathway: Apoptosis|||GPCR/G Protein|||Immunology/Inflammation|||MAPK|||Neuroscience|||NF-Κb
Target: NADPH-oxidase|||Beta Amyloid|||ASK|||IκB/IKK|||p38 MAPK|||TNF|||NOS|||NF-κB|||COX|||Prostaglandin Receptor
Receptor: N/A
Bioactivity: Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, it has a potential to be developed as a modulator of neuroinflammatory process in Alzheimer's disease. Neoechinulin A may ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities.
Molecular Weight: 323, 4