Product Overview
NEP(1-40) | TP1989 | TargetMol Chemicals
CAS: 475221-20-6
Smiles:
Formula: C206H324N56O65
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal growth, but does not reduce myelin-associated glycoprotein (MAG) inhibition of neurite outgrowth in vitro. Promotes regeneration of hemisected spinal axons and locomotor recovery following spinal injury in vivo.
Molecular Weight: 4625, 16
