Product Overview
NH-3 | T40548 | TargetMol Chemicals
CAS: 447415-26-1
Smiles: CC(C)C1=CC(CC2=C(C)C=C(OCC(O)=O)C=C2C)=CC(C#CC2=CC=C(C=C2)[N+]([O-])=O)=C1O
Formula: C28H27NO6
Pathway: Endocrinology/Hormones
Target: Thyroid hormone receptor(THR)
Receptor: N/A
Bioactivity: NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC 50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment.
Molecular Weight: 473, 52
