Product Overview
Niraparib hydrochloride | T3353 | TargetMol Chemicals
CAS: 1038915-64-8
Smiles: Cl.NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCCNC1
Formula: C19H21ClN4O
Pathway: Apoptosis|||Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Others
Target: Apoptosis|||Others|||PARP
Receptor: N/A
Bioactivity: Niraparib (MK-4827) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single-strand DNA breaks by the base-excision repair (BER) pathway.
Molecular Weight: 356, 85
