Product Overview
Niraparib tosylate monohyrate | T9497 | TargetMol Chemicals
CAS: 1613220-15-7
Smiles: O=S(C1=CC=C(C)C=C1)(O)=O.O=C(C2=CC=CC3=CN(C4=CC=C([C@H]5CNCCC5)C=C4)N=C23)N
Formula: C26H28N4O4S
Pathway: Chromatin/Epigenetic|||DNA Damage/DNA Repair
Target: PARP
Receptor: N/A
Bioactivity: Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.
Molecular Weight: 492, 59
