Niraparib tosylate monohyrate | T9497 | TargetMol Chemicals
Pathway: Chromatin/Epigenetic|||DNA Damage/DNA Repair
Bioactivity: Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.
Molecular Weight: 492, 59