Product Overview
Niraparib | T3231 | TargetMol Chemicals
CAS: 1038915-60-4
Smiles: NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCCNC1
Formula: C19H20N4O
Pathway: Apoptosis|||Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Others
Target: Apoptosis|||Others|||PARP
Receptor: N/A
Bioactivity: MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.
Molecular Weight: 320, 396
