Product Overview
Nutlin-3 | T2158 | TargetMol Chemicals
CAS: 548472-68-0
Smiles: COc1ccc(C2=NC(C(N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
Formula: C30H30Cl2N4O4
Pathway: Ubiquitination
Target: E1/E2/E3 Enzyme
Receptor: N/A
Bioactivity: Nutlin-3 is an MDM2 antagonist. Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells.
Molecular Weight: 581, 49
