Product Overview
Nutlin-3b | T6614 | TargetMol Chemicals
CAS: 675576-97-3
Smiles: COc1ccc(C2=N[C@@H]([C@@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
Formula: C30H30Cl2N4O4
Pathway: Apoptosis|||Ubiquitination
Target: Mdm2|||E1/E2/E3 Enzyme
Receptor: N/A
Bioactivity: Nutlin-3b is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
Molecular Weight: 581, 49
