Product Overview
Onalespib | T6284 | TargetMol Chemicals
CAS: 912999-49-6
Smiles: CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O
Formula: C24H31N3O3
Pathway: Cytoskeletal Signaling|||Metabolism
Target: HSP
Receptor: N/A
Bioactivity: Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins.
Molecular Weight: 409, 53
