Product Overview
OSI-027 | T6319 | TargetMol Chemicals
CAS: 936890-98-1
Smiles: COc1cccc2cc([nH]c12)-c1nc([C@H]2CC[C@@H](CC2)C(O)=O)n2ncnc(N)c12
Formula: C21H22N6O3
Pathway: Autophagy|||DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling
Target: DNA-PK|||PI3K|||mTOR|||Autophagy
Receptor: N/A
Bioactivity: OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. Phase 1.
Molecular Weight: 406, 446
