Product Overview
OSI-296 | T28271 | TargetMol Chemicals
CAS: 1175296-94-2
Smiles: C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl
Formula: C21H19Cl2FN4O3
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: OSI-296 is a potent and dual inhibitor of cMET and RON kinases (IC50 value are 42 nM and 200 nM for cMet and sfRon respectively) . OSI-206 shows in vivo efficacy and is well tolerated in tumor xenografts models upon oral dosing. OSI-296 also reduces tumour growth in the bone.
Molecular Weight: 465, 31
