Product Overview
PF-5274857 mseylate (1373615-35-0 free base) | T28388 | TargetMol Chemicals
CAS: T28388
Smiles: O=C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)CCS(=O)(C)=O.OS(=O)(C)=O
Formula: C21H29ClN4O6S2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates.
Molecular Weight: 533, 06
