Physalin H | TN4778

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Product Overview

Physalin H | TN4778 | TargetMol Chemicals

CAS: 70241-09-7

Smiles: C[C@@]12OC(=O)[C@]3(O)CC[C@H]4[C@@H](C[C@@H](O)[C@@]5(Cl)CC=CC(=O)[C@]45C)[C@]45O[C@@]13[C@H](C4=O)[C@]1(C)C[C@H]2OC(=O)[C@@H]1CO5

Formula: C28H31ClO10

Pathway: Autophagy|||Immunology/Inflammation|||Microbiology/Virology

Target: gp120/CD4|||Antifection|||Autophagy

Receptor: N/A

Bioactivity: Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both in vitro and in vivo, and the immunosuppressive activity might be attributed to the suppression of T cell activation and proliferation, the modulation of Th1/Th2 cytokine balance and the induction of HO-1 in T cells. Physalin H shows significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major.Physalin H shows cytotoxic activity against a panel of human and murine cancer cell lines.

Molecular Weight: 562, 99


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