Product Overview
PKR-IN-C16 | T16550 | TargetMol Chemicals
CAS: 608512-97-6
Smiles: O=C1Nc2ccc3ncsc3c2\C1=C\c1cnc[nH]1
Formula: C13H8N4OS
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR-IN-C16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.
Molecular Weight: 268, 29
