Product Overview
Pradefovir | T28449 | TargetMol Chemicals
CAS: 625095-60-5
Smiles: Nc1ncnc2n(CCOC[P@@]3(=O)OCC[C@H](O3)c3cccc(Cl)c3)cnc12
Formula: C17H19ClN5O4P
Pathway: Microbiology/Virology
Target: HBV
Receptor: N/A
Bioactivity: Pradefovir is a reverse transcriptase inhibitor potentially for treatment of chronic HBV infection. Pradefovir is also a liver-targeted prodrug of adefovir. After metabolic activation, Pradefovir was converted to PMEA (9-(2-phosphonylmethoxyethyl)adenine ) in human liver microsomes with a K(m) of 60 microM, a maximum rate of metabolism of 228 pmol/min/mg protein, and an intrinsic clearance of about 359 ml/min.
Molecular Weight: 423, 79
