Product Overview
(±)-Praeruptorin A | T4S1419 | TargetMol Chemicals
CAS: 73069-25-7
Smiles: C\C=C(\C)C(=O)OC1C(OC(C)=O)c2c(OC1(C)C)ccc1ccc(=O)oc21
Formula: C21H22O7
Pathway: Cytoskeletal Signaling|||MAPK|||Membrane transporter/Ion channel|||Metabolism|||PI3K/Akt/mTOR signaling
Target: p38 MAPK|||Calcium Channel|||Akt
Receptor: N/A
Bioactivity: 1. Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis. 3. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.
Molecular Weight: 386, 4
